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KMID : 0366919950070010049
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Sungkyun Pharmceutical Journal
1995 Volume.7 No. 1 p.49 ~ p.55
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Study on the Synthesis of Optically Active β-Hydroxy Amino Acid Derivatives, constituent of Bouvardin
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Abstract
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Abstract - Synthesis of the optically active unnatural β-hydroxy amino acid, which is building block of oligopeptide anticancer Bouvardin, was carried out for the total synthesis of Bouvardin. Oxazolidonic acid 2 was synthesized from p-bromobenzaldehyde as a starting material in 20% overall yield through five steps. And L-3-(3-hydroxy-4-methoxyphenyl)alanine methyl ester 3 was also synthesized from L-tyrosine in 46% overall yield using a known synthetic methodology. The Ullmann coupling reaction of amide 18 obtained from 2 and 3, was investigated under various reaction conditions.
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